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  • 1314092-14-2 Structure
  • Basic information

    1. Product Name: methyl 5-(3-cyano-2-nitrophenylamino)thiophene-2-carboxylate
    2. Synonyms: methyl 5-(3-cyano-2-nitrophenylamino)thiophene-2-carboxylate
    3. CAS NO:1314092-14-2
    4. Molecular Formula:
    5. Molecular Weight: 303.298
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1314092-14-2.mol
    9. Article Data: 1
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: methyl 5-(3-cyano-2-nitrophenylamino)thiophene-2-carboxylate(CAS DataBase Reference)
    10. NIST Chemistry Reference: methyl 5-(3-cyano-2-nitrophenylamino)thiophene-2-carboxylate(1314092-14-2)
    11. EPA Substance Registry System: methyl 5-(3-cyano-2-nitrophenylamino)thiophene-2-carboxylate(1314092-14-2)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1314092-14-2(Hazardous Substances Data)

1314092-14-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1314092-14-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,1,4,0,9 and 2 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1314092-14:
(9*1)+(8*3)+(7*1)+(6*4)+(5*0)+(4*9)+(3*2)+(2*1)+(1*4)=112
112 % 10 = 2
So 1314092-14-2 is a valid CAS Registry Number.

1314092-14-2Downstream Products

1314092-14-2Relevant articles and documents

Optimization of potent inhibitors of P. falciparum dihydroorotate dehydrogenase for the treatment of malaria

Skerlj, Renato T.,Bastos, Cecilia M.,Booker, Michael L.,Kramer, Martin L.,Barker, Robert H.,Celatka, Cassandra A.,O'Shea, Thomas J.,Munoz, Benito,Sidhu, Amar Bir,Cortese, Joseph F.,Wittlin, Sergio,Papastogiannidis, Petros,Angulo-Barturen, Inigo,Jimenez-Diaz, Maria Belen,Sybertz, Edmund

, p. 708 - 713 (2011/11/04)

Inhibition of dihydroorotate dehydrogenase (DHODH) for P. falciparum potentially represents a new treatment option for malaria, since DHODH catalyzes the rate-limiting step in the pyrimidine biosynthetic pathway and P. falciparum is unable to salvage pyrimidines and must rely on de novo biosynthesis for survival. We report herein the synthesis and structure-activity relationship of a series of 5-(2-methylbenzimidazol-1-yl)-N-alkylthiophene-2-carboxamides that are potent inhibitors against PfDHODH but do not inhibit the human enzyme. On the basis of efficacy observed in three mouse models of malaria, acceptable safety pharmacology risk assessment and safety toxicology profile in rodents, lack of potential drug-drug interactions, acceptable ADME/pharmacokinetic profile, and projected human dose, 5-(4-cyano-2-methyl-1H-benzo[d]imidazol-1-yl) -N-cyclopropylthiophene-2-carboxamide 2q was identified as a potential drug development candidate.

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