1314114-35-6Relevant articles and documents
Enantioselective base-free electrophilic amination of benzofuran-2(3H)- ones: Catalysis by binol-derived P-spiro quaternary phosphonium salts
Zhu, Chuan-Le,Zhang, Fa-Guang,Meng, Wei,Nie, Jing,Cahard, Dominique,Ma, Jun-An
supporting information; experimental part, p. 5869 - 5872 (2011/08/02)
A spiroing reactivity: A series of novel binol-derived P-spiro quaternary phosphonium salts were designed, prepared, and used for the first highly enantioselective amination of benzofuranones (see scheme; binol=1,1-2- binaphthol, Bn=benzyl). An unprecedented mechanism involving the π-π interactions between the substrate and the catalyst was proposed as the primary binding mode on the basis of molecular modelling and DFT calculations.
