1314140-00-5

Basic information

• Product Name: TC-N 22A
• Synonyms: TC-N 22A;N-pyridin-2-yl-4,5,6,7-tetrahydropyrazolo[2,3]cyclohepta[2,4-b][1,3]thiazol-2-amine
• CAS NO: 1314140-00-5
• Molecular Formula: C14H13N5S
• Molecular Weight: 283.35152
• Mol File: 1314140-00-5.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 603.5±58.0 °C(Predicted)
• Appearance: /
• Density: 1.435±0.06 g/cm3(Predicted)
• PKA: 11.98±0.20(Predicted)
• CAS DataBase Reference: TC-N 22A(CAS DataBase Reference)
• NIST Chemistry Reference: TC-N 22A(1314140-00-5)
• EPA Substance Registry System: TC-N 22A(1314140-00-5)

Safety Data

• Hazardous Substances Data: 1314140-00-5(Hazardous Substances Data)

Usage

Uses

TC-N 22A is a tricyclic thiazopyrazole derivative used as glutamate receptor 4 positive allosteric modulators used in the treatment of Parkinson’s disease, anxiety and pain.

Upstream product

• 499206-24-5 2-((dimethylamino)methylene)cycloheptane-1,3-dione 
• 1194-18-9 cycloheptane-1,3-dione 
• 14294-11-2 2-pyridylthiourea 
• 115215-89-9 5,6,7,8-tetrahydro-2H-cycloheptapyrazol-4-one 

Relevant articles and documents

Tricyclic thiazolopyrazole derivatives as metabotropic glutamate receptor 4 positive allosteric modulators

There is an increasing amount of evidence to support that activation of the metabotropic glutamate receptor 4 (mGlu4 receptor), either with an orthosteric agonist or a positive allosteric modulator (PAM), provides impactful interventions in diseases such as Parkinson's disease, anxiety, and pain. mGlu4 PAMs may have several advantages over mGlu4 agonists for a number of reasons. As part of our efforts in identifying therapeutics for central nervous system (CNS) diseases such as Parkinson's disease, we have been focusing on metabotropic glutamate receptors. Herein we report our studies with a series of tricyclic thiazolopyrazoles as mGlu4 PAMs.