1314140-40-3Relevant articles and documents
Asymmetric epoxidation of α,β-unsaturated ketones via an amine-thiourea dual activation catalysis
Zhang, Lu-Wen,Wang, Li,Ji, Nan,Dai, Si-Yang,He, Wei
, (2021)
A simple asymmetric epoxidation method is developed to effectively synthesize chiral α-carbonyl epoxides through an amine-thiourea dual activation catalysis. In this method, TBHP, as an oxidant, determined the reaction rate, and the chiral amine-thiourea catalyst effectively controlled the stereoselectivity of the reaction, and KOH promoted deprotonation. 22 examples of α,β-unsaturated ketones with various substituent groups are smoothly converted into α-carbonyl epoxides with moderate to excellent enantiomeric excess.
One-pot production of chiral α,β-epoxy ketones from benzaldehydes and acetophenones by recyclable poly(amino acid) catalysis
Luo, Wanrong,Yu, Zhichao,Qiu, Wenwei,Yang, Fan,Liu, Xiaofeng,Tang, Jie
supporting information; experimental part, p. 5289 - 5292 (2011/08/04)
An efficient one-pot, two-step process was disclosed for production of chiral α,β-epoxy ketones from benzaldehydes and acetophenones catalyzed by imidazolium-modified poly(l-leucine). Two effective reaction systems with complementary high enantioselectivities (up to 98% ee) or satisfactory yields (up to 89%) have been developed. Importantly, the poly(amino acid) catalyst can be easily recovered and recycled for ten times without losing its catalytic efficiency in terms of both enantioselectivity and yield.
