13142-48-8 Usage
General Description
1-(3,4-dichlorophenyl)-3-pyridin-3-ylurea is a chemical compound with the molecular formula C13H8Cl2N4O. It is a urea derivative with a pyridine ring and two chlorine atoms attached to the phenyl group. This chemical is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is known to have herbicidal properties and is used in the development of herbicides to control unwanted plant growth. Additionally, it has been studied for its potential as an anti-cancer agent and has shown promising results in inhibiting the growth of cancer cells. However, further research is needed to fully understand the potential applications and effects of 1-(3,4-dichlorophenyl)-3-pyridin-3-ylurea.
Check Digit Verification of cas no
The CAS Registry Mumber 13142-48-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,1,4 and 2 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 13142-48:
(7*1)+(6*3)+(5*1)+(4*4)+(3*2)+(2*4)+(1*8)=68
68 % 10 = 8
So 13142-48-8 is a valid CAS Registry Number.
13142-48-8Relevant articles and documents
Antischistosomal activity of N,N′-arylurea analogs against Schistosoma japonicum
Yao, Houzong,Liu, Fengyou,Chen, Jinglei,Li, Yan,Cui, Jinhao,Qiao, Chunhua
supporting information, p. 1386 - 1390 (2016/02/19)
Although the antischistosomal activities of N,N′-arylurea analogs were reported, systematic structure-activity relationships have not been conducted. In this Letter, we reported the design, synthesis and evaluation of 45 N,N′-arylurea analogs. Among these prepared compounds, 13 compounds were urea linker modified and 32 were N,N′-arylurea derivatives. The activity evaluation revealed 12 analogs exhibited IC50 values lower than 22.6 μM, and 7 of them had IC50 less than 10 μM against the juvenile Schistosoma japonicum in vitro. Their worm killing potency was even higher against adult worm. Unfortunately, low to moderate worm burden reduction of 0-33.4% was recorded after administration of a single oral dose of 200 mg/kg or 400 mg/kg to mice harboring S. japonicum.
