13142-55-7

Usage

Type of compound

Organic compound

Derived from

Phenylurea

Physical state

White crystalline solid

Solubility

Insoluble in water, soluble in organic solvents

Uses

Pesticide and herbicide

Mechanism of action

Inhibits the enzyme acetolactate synthase in plants

Effect on plants

Disrupts the production of branched-chain amino acids, leading to plant death

Additional use

Intermediate in the synthesis of other organic compounds

Safety precautions

Handle with caution, may be harmful if ingested or inhaled, can cause skin and eye irritation

Upstream product

• 590-28-3 potassium cyanate 
• 95-82-9 2,5 dichloroaniline 
• 1435-50-3 2-bromo-1,4-dichlorobenzene 
• 13142-18-2 C₁₄H₁₂Cl₂N₂O 
• 18995-49-8 2,5-dichlorophenylcyanamide 

Downstream Products

• 13201-85-9 1,3-bis(2,5-dichlorophenyl)urea 
• 1401252-81-0 3-(2,5-dichlorophenylureido)carbonyl-N₁-ethyl-6-hydroxy-4-oxo-pyrido[2,3-h]quinoline 

Relevant academic research and scientific papers

Green synthesis, optical properties and catalytic activity of silver nanoparticles in the synthesis of N-monosubstituted ureas in water

We report the green synthesis of silver nanoparticles by using Euphorbia condylocarpa M. bieb root extract for the synthesis of N-monosubstituted ureas in water. UV-visible studies show the absorption band at 420 nm due to surface plasmon resonance (SPR) of the silver nanoparticles. This reveals the reduction of silver ions (Ag+) to silver (Ago) which indicates the formation of silver nanoparticles (Ag NPs). This method has the advantages of high yields, simple methodology and easy work up.

Hybrid Pd/Fe3O4 nanowires: Fabrication, characterization, optical properties and application as magnetically reusable catalyst for the synthesis of N-monosubstituted ureas under ligand-free conditions

This paper reports the synthesis and use of Pd/Fe3O4 nanowires, as magnetically separable catalysts for ligand-free amidation coupling reactions of aryl halides with benzylurea under microwave irradiation. Then, the in situ hydrogenolysis of the products was performed to afford the N-monosubstituted ureas from good to excellent yields. This method has the advantages of high yields, simple methodology and easy work up. The catalyst can be recovered by using a magnet and reused several times without significant loss of its catalytic activity. The catalyst was characterized using the powder XRD, SEM, EDS and UV-vis spectroscopy. Experimental absorbance spectra was compared with results from the Gans theory.

Spiroquinazolinones as novel, potent, and selective PDE7 inhibitors. Part 2: Optimization of 5,8-disubstituted derivatives

The optimization of 5,8-disubstituted spirocyclohexane-quinazolinones into potent, selective, soluble PDE7 inhibitors with acceptable in vivo pharmacokinetic parameters is presented.