13142-91-1Relevant academic research and scientific papers
UREA SUBSTITUTED SULPHONAMIDE DERIVATIVES
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Page/Page column 57; 63, (2010/12/31)
The present invention relates to sulphonamide derivatives, whith a urea moiety. The invention also relates to the use of the derivatives as inhibitors of collagen receptor integrins, especially α2β1 integrin inhibitors e.g. in connection with diseases and
Unsymmetrically disubstituted urea derivatives: A potent class of antiglycating agents
Khan, Khalid M.,Saeed, Sumayya,Ali, Muhammad,Gohar, Madiha,Zahid, Javariya,Khan, Ambreen,Perveen, Shahnaz,Choudhary, M. Iqbal
experimental part, p. 2447 - 2451 (2009/09/05)
A series of unsymmetrically disubstituted urea derivatives 1-28 has been synthesized and screened for their antiglycation activity in vitro. Compounds 26 (IC50 = 4.26 ± 0.25 μM), 1 (IC50 = 5.8 ± 0.08 μM), 22 (IC50 = 4.26 ± 0.25 μM), 6 (IC50 = 6.4 ± 0.02 μM), 5 (IC50 = 6.6 ± 0.26 μM), 2 (IC50 = 7.02 ± 0.31 μM), 3 (IC50 = 7.14 ± 0.84 μM), 27 (IC50 = 7.27 ± 0.36 μM), 4 (IC50 = 8.16 ± 1.04 μM), 21 (IC50 = 8.4 ± 0.15 μM), 23 (IC50 = 9.0 ± 0.35 μM) and 13 (IC50 = 15.22 ± 6.7 μM) showed an excellent antiglycation activity far better than the standard (rutin, IC50 = 41.9 ± 2.3 μM). This study thus provides a series of potential molecules for further studies of antiglycation agents.
