1314230-69-7 Usage
Biological Activity
ki: 0.6 nm4-quinolone-3-carboxamide cb2 ligand is a ligand of the cb2 receptor.cannabinoids (cbs) and their synthetic analogs exhibit biochemical and pharmacological effects via interacting with the central cb1 and peripheral cb2 receptors. the cb2 receptor has emerged as a pharmacological target for treating osteoporosis, and for eliciting antinociceptive effects in various pain models .
in vitro
previous study found that 4-quinolone-3-carboxamide cb2 ligand was a selective, high-affinity ligand of the cb2 receptor, displaying an in vitro ki values of 0.6 nm for cb2 and over 10,000 nm for cb1 [1].
in vivo
in animal study, it was found that 4-quinolone-3-carboxamide cb2 ligand at a dose of 6 mg/kg showed antinociceptive activity in a formalin test of nocifensive response in mice. moreover, such analgesic affect could not be significantly reversed by the cb2 antagonist am630 treatment, which suggested that 4-quinolone-3-carboxamide cb2 ligand might behave as an inverse agonist [1].
references
[1] s. pasquini, m. de rosa, v. pedani, et al. investigations on the 4-quinolone-3-carboxylic acid motif. 4. identification of new potent and selective ligands for the cannabinoid type 2 receptor with diverse substitution patterns and antihyperalgesic effects in mice. journal of medicinal chemistry 54, 5444-5453 (2011).
Check Digit Verification of cas no
The CAS Registry Mumber 1314230-69-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,1,4,2,3 and 0 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1314230-69:
(9*1)+(8*3)+(7*1)+(6*4)+(5*2)+(4*3)+(3*0)+(2*6)+(1*9)=107
107 % 10 = 7
So 1314230-69-7 is a valid CAS Registry Number.
1314230-69-7Relevant articles and documents
Investigations on the 4-quinolone-3-carboxylic acid motif. 4. Identification of new potent and selective ligands for the cannabinoid type 2 receptor with diverse substitution patterns and antihyperalgesic effects in mice
Pasquini, Serena,De Rosa, Maria,Pedani, Valentina,Mugnaini, Claudia,Guida, Francesca,Luongo, Livio,De Chiaro, Maria,Maione, Sabatino,Dragoni, Stefania,Frosini, Maria,Ligresti, Alessia,Di Marzo, Vincenzo,Corelli, Federico
, p. 5444 - 5453 (2011/09/30)
Experimental evidence suggests that selective CB2 receptor modulators may provide access to antihyperalgesic agents devoid of psychotropic effects. Taking advantage of previous findings on structure-activity/selectivity relationships for a class of 4-quin
