1314335-49-3Relevant articles and documents
Anti-markovnikov hydroalkylation of allylic amine derivatives via a palladium-catalyzed reductive cross-coupling reaction
Deluca, Ryan J.,Sigman, Matthew S.
supporting information; experimental part, p. 11454 - 11457 (2011/10/02)
Palladium-catalyzed hydroalkylation of allylic amine derivatives by alkylzinc reagents is reported. This reductive cross-coupling reaction yields anti-Markovnikov products using a variety of allylic amine protecting groups. Preliminary mechanistic studies suggest that a reversible β-hydride elimination/hydride insertion process furnishes the primary Pd-alkyl intermediate, which then undergoes transmetalation followed by reductive elimination to form a new sp3-sp3 carbon-carbon bond.
