131438-79-4

Basic information

• Product Name: AMYLOID BETA-PROTEIN (HUMAN, 1-40) TRIFLUOROACETATE
• Synonyms: AMYLOID B-PROTEIN FRAGMENT 1-40;Amyloidb-Peptide(1-40)(human);H-Asp-Ala-Glu-Phe-Gly-His-Asp-Ser-Gly-Phe-Glu-Val-Arg-His-Asp-Ser-Gly-Phe-Glu-Val-Arg-His-Gln-Lys-Leu-Val-Gly-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH;amyloid β protein fragment 1-40;aβ40;SS-AMYLOID (1-40), RAT;M.W. 4329.86 C194H295N53O58S;beta Amyloid (1-40) human
• CAS NO: 131438-79-4
• Molecular Formula: C194H295N53O58S
• Molecular Weight: 4329.8034
• Product Categories: Peptide;Amyloid beta-peptide and related;Neuroscience;proteins
• Mol File: 131438-79-4.mol
• Article Data: 0

Chemical Properties

• Appearance: white/powder
• Storage Temp.: −20°C
• Solubility: H2O: ~6 mg/mL
• CAS DataBase Reference: AMYLOID BETA-PROTEIN (HUMAN, 1-40) TRIFLUOROACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: AMYLOID BETA-PROTEIN (HUMAN, 1-40) TRIFLUOROACETATE(131438-79-4)
• EPA Substance Registry System: AMYLOID BETA-PROTEIN (HUMAN, 1-40) TRIFLUOROACETATE(131438-79-4)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 131438-79-4(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 131438-79-4 differently. You can refer to the following data:
1. Amyloid β-protein is neurotrophic and neurotoxic in vivo and in vitro in human and rat neuronal cell cultures. β-Amyloid peptides (amino acids 1-42 and 1-43) are the major constituents of senile plaques and neurofibrillary tangles that occur in the hippoc
2. Amyloid β Protein Fragment 1-40 has been used:in the temperature based conformational studies using Fourier transform infrared/differential scanning calorimetry (FT-IR/DSC) studiesas a reference standard in sandwich-type enzyme immunoassay for quantifying amyloid A4 protein in cerebrospinal fluid of patients with head traumaas a component of embryonic stem cell medium to inhibit amyloid deposition in fibroblasts

General Description

Amyloid β Protein Fragment 1-40 (Aβ40) is derived from the amyloid-β protein (Aβ), which is mapped to human chromosome 21q21.3. Aβ40 is predominantly present in the vascular amyloid deposits. Aβ40 comprises of C-terminal membrane insertion domain. It shows structural transition from random coil to a α-helical structure in a water-micelle medium.

Biological Activity

amyloid β-peptide (1-40) (human), (c194h295n53o58s1), a peptide with the sequence h2n-daefrhdsgyevhhqklvffaedvgsnkgaiiglmvggvvia-oh, mw= 4329.8. amyloid beta (aβ or abeta) is a peptide of 36-43 amino acids that is processed from the amyloid precursor protein. while best known as a component of amyloid plaques in association with alzheimer's disease, evidence has been found that aβ is a highly multifunctional peptide with significant non-pathological activity(1). aβ is the main component of deposits found in the brains of patients with alzheimer's disease. brain aβ is elevated in patients with sporadic alzheimer’s disease. aβ is the main constituent of brain parenchymal and vascular amyloid, it contributes to cerebrovascular lesions and is neurotoxic(2). aβ protein is generated by successive action of the β and γ secretases. the γ secretase, which produces the c-terminal end of the aβ peptide, cleaves within the transmembrane region of app and can generate a number of isoforms of 36-43 amino acid residues in length. the most common isoforms are aβ40 and aβ42; the longer form is typically produced by cleavage that occurs in the endoplasmic reticulum, while the shorter form is produced by cleavage in the trans-golgi network(3).figure1 structure of amyloid β-peptide (1-40) (human)

Biochem/physiol Actions

Amyloid β-protein is neurotrophic and neurotoxic in vivo and in vitro in human and rat neuronal cell cultures. β-Amyloid peptides (amino acids 1-42 and 1-43) are the major constituents of senile plaques and neurofibrillary tangles that occur in the hippocampus, neocortex, and amygdala of patients with Alzheimer′s disease.

references

1. Lahiri DK, Maloney B (September 2010). "Beyond the signaling effect role of amyloid–β42 on the processing of AβPP, and its clinical implications". Exp. Neurol. 225 (1): 51-4.2. Hardy J, Duff K, Hardy KG, Perez-Tur J, Hutton M (September 1998). "Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau". Nat. Neurosci. 1 (5): 355-8.3. Hartmann T, Bieger SC, Brühl B, Tienari PJ, Ida N, Allsop D, Roberts GW, Masters CL, Dotti CG, Unsicker K, Beyreuther K (September 1997). "Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides". Nat. Med. 3 (9): 1016-20.