1314419-49-2

Upstream product

• 1194-02-1 4-fluorobenzonitrile 
• 56108-05-5 4-fluorobenzamidic acid methylester hydrochloride salt 
• 5619-04-5 methyl 2-amino-3-hydroxypropanoate hydrochloride 
• 52778-94-6 methyl 2-[(4-fluorophenyl)carbonylamino]-3-hydroxypropanoate 

Downstream Products

• 885273-80-3 (2-(4-fluorophenyl)oxazol-4-yl)methanol 
• 1065102-64-8 methyl 2-(4-fluorophenyl)-1,3-oxazole-4-carboxylate 
• 152940-51-7 2-(4-fluorophenyl)oxazole-4-carbaldehyde 
• 1314887-37-0 2-(2-(4-fluorophenyl)oxazol-4-yl)-2-hydroxyacetonitrile 

Relevant academic research and scientific papers

COMPOUNDS AND METHODS for the inhibition of HDAC

Disclosed are compounds having the formula: wherein X1, X2, X3, R1, R2, R3, R4, Y, A, Z, L and n are as defined herein, and methods of making and using the same.

COMPOUNDS AND METHODS

Disclosed are compounds having the formula: wherein X1, X2, X3, R1, R2, R3, R4, Y, A, n and L are as defined herein, and methods of making and using the same.

SUBSTITUTED HETEROCYCLIC COMPOUNDS USEFUL IN THE TREATMENT OF CARDIOVASCULAR DISEASES

wherein: a.o. T is oxygen, sulfur, or NR11 , in which R11 is hydrogen or lower alkyl; V is -N1 is hydrogen, optionally substituted lower alkyl, optionally substituted cycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl; X2 is optionally substituted aryl or optionally substituted heteroaryl; Y is optionally substituted dihydroheteroarcyl; and Z1 and Z2 are independently optionally substituted alkylene of 1-4 carbon atoms, useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal’s (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, and myocardial infarction. The compounds are also useful in the treatment of diabetes.