1314531-95-7Relevant academic research and scientific papers
Expeditious convergent procedure for the preparation of bis(POC) prodrugs of new (E)-4-phosphono-but-2-en-1-yl nucleosides
Montagu, Aurélien,Pradére, Ugo,Roy, Vincent,Nolan, Steven P.,Agrofoglio, Luigi A.
experimental part, p. 5319 - 5328 (2011/08/06)
A series of unsaturated acyclonucleoside bis(POC) prodrugs of E configuration were synthesized through an expeditious, highly efficient and stereoselective one-step procedure from corresponding bis(POC)allylphosphonate through Ru catalyzed cross-coupling metathesis reaction. The [RuCl 2(PCy3)(SIPr)(Indenylidene)] and [RuCl 2(PCy3)(IMes)(benzylidene)] catalysts were employed; the unsaturated ANP were used bore C5-halovinyl uracil, C5-dihalovinyluracil or furanopyrimidine motifs. The chemical cleavage of biolabile (POC) group is a useful pathway to acid phosphonate derivatives.
