1314641-64-9

Upstream product

• 202865-68-7 3-bromo-4-fluoro-benzylamine hydrochloride 
• 1314641-62-7 N-(3-bromo-4-fluoro-benzyl)-2,2,2-trifluoroacetamide 
• 1314641-63-8 3-{2-fluoro-5-[(2,2,2-trifluoro-acetylamino)-methyl]-phenyl}-8-aza-bicyclo[3.2.1]oct-2-ene-8-carboxylic acid tert-butyl ester 
• 185099-67-6 Boc-tropinone 
• 185099-68-7 tert‐butyl 3‐(trifluoromethanesulfonyloxy)‐8‐azabicyclo[3.2.1]oct‐2‐ene‐8‐carboxylate 

Downstream Products

• 1314641-65-0 N-[3-(8-aza-bicyclo[3.2.1]oct-3-yl)-4-fluoro-benzyl]-2,2,2-trifluoro-acetamide hydrochloride 
• 1314641-69-4 N-{3-[8-(4-bromo-3-methyl-5-propoxy-thiophene-2-carbonyl)-8-azabicyclo[3.2.1]oct-3-yl]-4-fluoro-benzyl}-2,2,2-trifluoro-acetamide 
• 1314641-61-6 [3-(5-aminomethyl-2-fluoro-phenyl)-8-aza-bicyclo[3.2.1]oct-8-yl]-(4-bromo-3-methyl-5-propoxy-thiophen-2-yl)-methanone hydrochloride 

Relevant academic research and scientific papers

A β-tryptase inhibitor with a tropanylamide scaffold to improve in vitro stability and to lower hERG channel binding affinity

Tropanylamide was investigated as a possible scaffold for b-tryptase inhibitors with a basic benzylamine P1 group and a substituted thiophene P4 group. Comparing to piperidinylamide, the tropanylamide scaffold is much more rigid, which presents less oppor