1314642-49-3Relevant academic research and scientific papers
The catalytic addition of alkyl boranes to alkynyl esters affording single-isomer trisubstituted olefins
Rajagopal, Thivisha,Ogilvie, William W.
, p. 1113 - 1116 (2011/06/20)
The generation of a series of trisubstituted olefins bearing alkyl substituents is described using a stereoselective and regio-selective addition to alkynyl esters. The method produces trisubstituted olefins as single isomers using a convenient and mild transformation in which alkyl boranes are cross-coupled with alkynyl esters and amides using palladium catalysis. Georg Thieme Verlag Stuttgart - New York.
Single isomer trisubstituted olefins bearing alkyl groups
Rajagopal, Thivisha,Flynn, Alison B.,Ogilvie, William W.
experimental part, p. 8739 - 8744 (2011/01/04)
E-β-Chloro-α-iodo-α,β-unsaturated esters were converted to single isomer trisubstituted olefins bearing alkyl substituents by using and alkyl-Suzuki cross coupling. The process was highly selective, and the products in all cases were isolated as single isomers. Mechanistic investigations indicated that this process transfers a hydrogen from water to the α-position of the substrate, and then an alkyl group is introduced to the β-position of the intermediate template while replacing a chloride.
