1314654-11-9Relevant academic research and scientific papers
GAMMA AMINO ACID BUILDING BLOCKS
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, (2011/05/05)
The invention provides compounds and methods, for example, to carry out organocatalytic Michael additions of aldehydes to cyclically constrained nitroethylene compounds catalyzed by a pro line derivative to provide cyclically constrained α-substituted-γ-n
Characteristic structural parameters for the γ-peptide 14-helix: Importance of subunit preorganization
Guo, Li,Zhang, Weicheng,Reidenbach, Andrew G.,Giuliano, Michael W.,Guzei, Ilia A.,Spencer, Lara C.,Gellman, Samuel H.
supporting information; scheme or table, p. 5843 - 5846 (2011/08/06)
All wound up: Crystallographic data for a set of homologous peptides constructed from gabapentin and two to six preorganized γ-amino acid residues (see crystal structure of the longest peptide) allow derivation of characteristic parameters for the γ-peptide 14-helix and establish guidelines for characterizing 14-helical folding. The results suggest that the substitution pattern of a γ-residue has a profound effect on the propensity for 14-helical folding.
