1314713-66-0

Basic information

• Product Name: (Z)-2-(4-butylbenzylidene)-4-hydroxybenzofuran-3(2H)-one
• CAS NO: 1314713-66-0
• Molecular Weight: 294.35
• Mol File: 1314713-66-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (Z)-2-(4-butylbenzylidene)-4-hydroxybenzofuran-3(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-2-(4-butylbenzylidene)-4-hydroxybenzofuran-3(2H)-one(1314713-66-0)
• EPA Substance Registry System: (Z)-2-(4-butylbenzylidene)-4-hydroxybenzofuran-3(2H)-one(1314713-66-0)

Safety Data

• Hazardous Substances Data: 1314713-66-0(Hazardous Substances Data)

Upstream product

• 26674-05-5 acetic acid 2-acetyl-3-hydroxyphenyl ester 
• 19278-81-0 4-hydroxy-1-benzofuran-3(2H)-one 
• 1200-14-2 4-(n-butyl)benzaldehyde 

Relevant articles and documents

Discovery of naturally occurring aurones that are potent allosteric inhibitors of hepatitis C virus RNA-dependent RNA polymerase

We have identified naturally occurring 2-benzylidenebenzofuran-3-ones (aurones) as new templates for non-nucleoside hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp) inhibitors. The aurone target site, identified by site-directed mutagenesis, is located in thumb pocket I of HCV RdRp. The RdRp inhibitory activity of 42 aurones was rationally explored in an enzyme assay. Molecular docking studies were used to determine how aurones bind to HCV RdRp and to predict their range of inhibitory activity. Seven aurone derivatives were found to have potent inhibitory effects on HCV RdRp, with IC50 below 5 μM and excellent selectivity index (inhibition activity versus cellular cytotoxicity). The most active aurone analogue was (Z)-2-((1-butyl-1H-indol-3-yl)methylene)-4,6-dihydroxybenzofuran-3(2H)-one (compound 51), with an IC50 of 2.2 μM. Their potent RdRp inhibitory activity and their low toxicity make these molecules attractive candidates as direct-acting anti-HCV agents.