13148-05-5Relevant articles and documents
Discovery of 5-(4-hydroxyphenyl)-3-oxo-pentanoic acid [2-(5-methoxy-1H- indol-3-yl)-ethyl]-Amide as a neuroprotectant for Alzheimers Disease by Hybridization of Curcumin and Melatonin
Chojnacki, Jeremy E.,Liu, Kai,Yan, Xing,Toldo, Stefano,Selden, Tyler,Estrada, Martin,Rodríguez-Franco, María Isabel,Halquist, Matthew S.,Ye, Dexian,Zhang, Shijun
, p. 690 - 699 (2014)
In our effort to develop effective neuroprotectants as potential treatments for Alzheimer"s disease (AD), hybrid compounds of curcumin and melatonin, two natural products that have been extensively studied in various AD models, were designed, synthesized,
Synthesis and biological activity of alkylidene-substituted cephems and penams
Potorocina,Vorona,Shestakova,Domracheva,Liepinsh,Veinberg
, p. 767 - 775 (2011)
The condensation of tert-butyl esters of 3-methyl-7-oxoceph-3-em-4- carboxylic and 6-oxopenicillanic acids with a series of 2- oxoalkylidene(triphenyl)phosphoranes gave tert-butyl esters of new cephalosporin and penicillin analogs with an alkylidene substituent in the β-lactam ring. Most of these products were oxidized by meta-chloroperbenzoic acid to the corresponding sulfones. The cephemes and penams synthesized including the oxidized products displayed high cytotoxicity relative to cancer cells in vitro. Some of the alkylidene-substituted cephems as the free acids, similar to Tazobactam, inhibit the catalytic activity of Enterobacter cloacae penicillinase.
The first chemical synthesis of pyrazofurin 5′-triphosphate
Huang, Hua-Shan,Wang, Rui,Chen, Wei-Jie,Chen, Ji-Zong,Gong, Shan-Shan,Sun, Qi
supporting information, p. 3423 - 3427 (2018/08/17)
As an archetype C-nucleoside, pyrazofurin possesses broad-spectrum antiviral and antitumor activities. However, the presence of the acidic enol in the nucleobase of pyrazofurin poses a huge challenge to the conventional NTP synthetic methods. On the basis
