13148-14-6

Basic information

• Product Name: 2,3-DIHYDRO-2-PHENYL-3-SPIROEPOXY-1H-INDANONE
• Synonyms: SPECS AJ-091/33875031;2,3-DIHYDRO-2-PHENYL-3-SPIROEPOXY-1H-INDANONE;3'-Phenylspiro[indene-2,2'-oxiran]-1(3H)-one
• CAS NO: 13148-14-6
• Molecular Formula: C₁₆H₁₂O₂
• Molecular Weight: 236.27
• Mol File: 13148-14-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 415.1°C at 760 mmHg
• Flash Point: 199.3°C
• Appearance: /
• Density: 1.29g/cm³
• Vapor Pressure: 4.24E-07mmHg at 25°C
• Refractive Index: 1.665
• CAS DataBase Reference: 2,3-DIHYDRO-2-PHENYL-3-SPIROEPOXY-1H-INDANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-DIHYDRO-2-PHENYL-3-SPIROEPOXY-1H-INDANONE(13148-14-6)
• EPA Substance Registry System: 2,3-DIHYDRO-2-PHENYL-3-SPIROEPOXY-1H-INDANONE(13148-14-6)

Safety Data

• Hazardous Substances Data: 13148-14-6(Hazardous Substances Data)

Usage

Structure

Contains a spiroepoxy group and a phenyl ring.

Type

Synthetic chemical compound.

Usage

Commonly used as a building block for the synthesis of pharmaceuticals and other organic compounds.

Medicinal properties

Studied for its potential medicinal properties, including anti-inflammatory and analgesic effects.

Drug development potential

Promising candidate for drug development due to its medicinal properties.

Neurological disorder treatment potential

Investigated for its potential use in the treatment of neurological disorders such as Parkinson's disease and Alzheimer's disease.

Versatility

Versatile chemical with potential applications in the pharmaceutical and biomedical fields.

InChI:InChI=1/C16H12O2/c17-14-13-9-5-4-8-12(13)10-16(14)15(18-16)11-6-2-1-3-7-11/h1-9,15H,10H2

Upstream product

• 5706-12-7 (E)-2-benzylidene-2,3-dihydro-1H-inden-1-one 
• 5706-12-7 2-benzylidine-1-indanone 
• 17598-66-2 2-benzylidene-indan-1-one 
• 7722-84-1 dihydrogen peroxide 

Relevant articles and documents

Highly efficient alkene epoxidation and aziridination catalyzed by iron(II) salt + 4,4′,4″-trichloro-2,2′:6′,2″-terpyridine/ 4,4″-dichloro-4′-O-PEG-OCH3-2,2′:6′,2″- terpyridine

(Chemical Equation Presented) "Iron(II) salt + 4,4′,4″- trichloro-2,2′:6′,2″-terpyridine" is an effective catalyst for epoxidation and aziridination of alkenes and intramolecular amidation of sulfamate esters. The epoxidation of allylic-substituted cycloalkenes achieved excellent diastereoselectivities up to 90%. ESI-MS results supported the formation of iron-oxo and -imido intermediates. Derivitization of Cl3terpy to O-PEG-OCH3-Cl2terpy renders the terpyridine unit to be recyclable, and the "iron(II) salt + 4,4″-dichloro-4′-O-PEG-OCH3-2,2′:6′,2″- terpyridine" protocol can be reused without a significant loss of catalytic activity in the alkene epoxidation.

Stereoselective Epoxidation of 2-Arylidene-1-indanones and 2-Arylidene-1-benzosuberones

Oxidation of the (E) and (Z) isomers of 2-arylidene-1-indanones (1) and 2-arylidene-1-benzosuberones (4) by alkaline hydrogen peroxide (method i) afforded the spiroepoxides trans-2a-g and trans-5a-g from both isomers as sole products in high yields.On the