1314871-51-6Relevant articles and documents
Selective Inhibition of iNOS by Benzyl- and Dibenzyl Derivatives of N-(3-Aminobenzyl)acetamidine
Fantacuzzi, Marialuigia,Maccallini, Cristina,Lannutti, Fabio,Patruno, Antonia,Masella, Simona,Pesce, Mirko,Speranza, Lorenza,Ammazzalorso, Alessandra,De Filippis, Barbara,Giampietro, Letizia,Re, Nazzareno,Amoroso, Rosa
, p. 1203 - 1206 (2012/04/18)
Picking your NOS: The effect of amine substitution at the 3-aminomethyl group of known iNOS inhibitor W1400 with mono- or disubstituted benzylic groups was evaluated. The o-nitro-benzyl derivative was identified as a potent inhibitor of iNOS, with good selectivity over eNOS. Docking simulations were performed to predict the binding mode of these derivatives in the iNOS and eNOS active sites.
