1314908-30-9

Basic information

• Product Name: indolin-6-ylmethanol
• CAS NO: 1314908-30-9
• Molecular Weight: 149.192
• Mol File: 1314908-30-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: indolin-6-ylmethanol(CAS DataBase Reference)
• NIST Chemistry Reference: indolin-6-ylmethanol(1314908-30-9)
• EPA Substance Registry System: indolin-6-ylmethanol(1314908-30-9)

Safety Data

• Hazardous Substances Data: 1314908-30-9(Hazardous Substances Data)

Upstream product

• 350683-40-8 2,3-dihydro-1H-indole-6-carboxylic acid ethyl ester 
• 1075-26-9 6-(hydroxymethyl)indole 
• 50820-65-0 indole-6-carboxylic acid methyl ester 
• 341988-36-1 2,3-dihydro-1H-indole-6-carboxylic acid methyl ester 

Relevant articles and documents

IMIDAZOPYRIDAZINE AND IMIDAZOTHIADIAZOLE COMPOUNDS

The present invention provides imidazopyridazine compounds or imidazothiadiazole compounds of Formula I having the structure: (I) wherein X1, X2, X3, X4, X5, Y, W, R1, R2, R

A novel series of thromboxane A2 synthetase inhibitors with free radical scavenging and anti-peroxidative activities

A novel series of indoline derivatives with imidazole and carboxyl moieties were synthesized and evaluated for their thromboxane A2 (TXA2) synthetase inhibiting, radical scavenging and anti-peroxidative activities. Among the compounds synthesized, 3.{5-substituted-3-[2-(imidazol-1-yl)ethyl]indolin-1-yl}propionic acids showed free radical scavenging activity and inhibitory effects on lipid-peroxidation of rat brain homogenate and on arachidonate-induced TXA2-dependent aggregation of rabbit platelets. The anti-platelet and anti-peroxidative activities were related to the lipophilicity of the 5-substituent. The 5-hexyloxy derivative (13) showed about 35-fold higher inhibitory activity on TXA2 synthesis than that of ozagrel and about 100-fold higher activity on lipid peroxidation than that of α-tocopherol. Compound 13 showed in vivo anti-thrombotic effect in mice and ex vivo anti-peroxidative activity in rats.