1314920-72-3Relevant articles and documents
Practical synthesis of pyrazoles via a copper-catalyzed relay oxidation strategy
Tang, Xiaodong,Huang, Liangbin,Yang, Jidan,Xu, Yanli,Wu, Wanqing,Jiang, Huanfeng
supporting information, p. 14793 - 14796 (2014/12/11)
Various 1,3- and 1,3,4-substituted pyrazoles are smoothly formed via copper-catalyzed cascade reactions of oxime acetates, amines and aldehydes. This relay oxidative process involves copper-promoted N-O bond cleavage and C-C/C-N/N-N bond formations to furnish pyrazolines, and sequential Cu-O2 system-involved oxidative dehydrogenation of pyrazolines to afford pyrazoles. This transformation provides a novel and versatile approach for the synthesis of pyrazoles, with an inexpensive copper catalyst and green oxidants. It is atom- and step-economical, and possesses a good functional group tolerance, as well as operational simplicity. This journal is
An efficient regioselective copper catalyzed multi-component synthesis of 1,3-disubstituted pyrazoles
Raghunadh, Akula,Meruva, Suresh Babu,Mekala, Ramamohan,Raghavendra Rao,Krishna, Thalishetti,Gangadhara Chary,Vaikunta Rao,Syam Kumar
, p. 2986 - 2990 (2014/05/06)
An efficient synthesis of unsymmetrically substituted 1,3-pyrazole derivatives has been developed via three-component coupling reaction involving 3-(dimethylamino)-1-phenylprop-2-en-1-one, hydrazine, and aryl halides in one pot process exhibiting high regioselectivity. The pyrazole synthesis proceeds via a sequential series of reactions such as Michael addition, heterocyclization, dehydration, and Ullmann cross-coupling.
Cu(OAc)2·H2O-catalyzed N-arylation of nitrogen-containing heterocycles
Xu, Zhong-Lin,Li, Hong-Xi,Ren, Zhi-Gang,Du, Wei-Yuan,Xu, Wei-Chang,Lang, Jian-Ping
supporting information; experimental part, p. 5282 - 5288 (2011/08/04)
In the absence of any additional ligands, the efficient N-arylation of nitrogen-containing heterocycles with aryl iodides catalyzed by relative low catalyst amount of Cu(OAc)2·H2O was developed. This simple catalytic system is involved in the C-N cross-coupling reaction and works for a variety of pyrazole, pyrrole, imidazole, triazole, indole, benzoimidazole, benzotriazole, carbazole, and anilines as well as aryl iodides with different electronic properties. Highly efficient copper(II)-catalyzed N-arylation protocol was established.
