1314960-09-2

Basic information

• Product Name: C₇H₉FN₂O
• Synonyms: C₇H₉FN₂O
• CAS NO: 1314960-09-2
• Molecular Weight: 156.16
• Mol File: 1314960-09-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₇H₉FN₂O(CAS DataBase Reference)
• NIST Chemistry Reference: C₇H₉FN₂O(1314960-09-2)
• EPA Substance Registry System: C₇H₉FN₂O(1314960-09-2)

Safety Data

• Hazardous Substances Data: 1314960-09-2(Hazardous Substances Data)

Upstream product

• 202925-08-4 1-chloro-3-fluoro-5-methoxybenzene 

Relevant articles and documents

Diversification of edaravone via palladium-catalyzed hydrazine cross-coupling: Applications against protein misfolding and oligomerization of beta-amyloid

N-Aryl derivatives of edaravone were identified as potentially effective small molecule inhibitors of tau and beta-amyloid aggregation in the context of developing disease-modifying therapeutics for Alzheimer's disease (AD). Palladium-catalyzed hydrazine monoarylation protocols were then employed as an expedient means of preparing a focused library of 21 edaravone derivatives featuring varied N-aryl substitution, thereby enabling structure-activity relationship (SAR) studies. On the basis of data obtained from two functional biochemical assays examining the effect of edaravone derivatives on both fibril and oligomer formation, it was determined that derivatives featuring an N-biaryl motif were four-fold more potent than edaravone.