1314975-69-3Relevant academic research and scientific papers
Bridging homogeneous and heterogeneous catalysis with CAN·SiO2 as a solid catalyst for four-component reactions for the synthesis of tetrasubstituted pyrroles
Atar, Amol B.,Kim, Jong Su,Lim, Kwon Taek,Jeong, Yeon Tae
, p. 396 - 402 (2015)
An efficient and expeditious method has been developed for the synthesis of tetrasubstituted pyrroles via a four component, one-pot cyclocondensation reaction of amines, aldehydes, dialkyl acetylenedicarboxylates and nitroalkanes using silica supported ceric ammonium nitrate as a heterogeneous catalyst for the first time. Reusable silica supported ceric ammonium nitrate was found to be a highly efficient and renewable heterogeneous catalyst for the rapid and convenient synthesis of tetrasubstituted pyrrole derivatives. The advantageous features of this novel methodology are high atom-economy, operational simplicity, shorter reaction times, convergence, and facile automation.
A solvent and transition metal-free, highly efficient Br?nsted acidic ionic liquid promoted one-potthree-component reactions for the synthesis of tetrasubstituted pyrroles
Balu Atar, Amol,Han, Eunbi,Sohn, Dae Hyup,Kang, Jongmin
supporting information, p. 1181 - 1192 (2019/04/05)
The present protocol describes a highly efficient, transition metal and solvent-free one-pot annulation of amines, dialkyl acetylenedicarboxylates and β-nitrostyrene using imidazolium Br?nsted acidic ionic liquid for the synthesis of tetrasubstituted pyrroles. A diverse functionalized tetrasubstituted pyrroles derivatives were obtained with excellent yields under transition metal and solvent-free conditions. The Br?nsted acidic ionic liquid can be easily recovered and reused for the next reaction without any effects on the yields of the products. This green protocol provides structurally complex, medicinally important tetrasubstituted pyrroles with various substitution patterns in a one-pot operation.
An efficient one-pot synthesis of tetra-substituted pyrroles
Ghabraie, Elmira,Balalaie, Saeed,Bararjanian, Morteza,Bijanzadeh, Hamid Reza,Rominger, Frank
experimental part, p. 5415 - 5420 (2011/08/06)
The three-component reaction of primary amines, dialkyl acetylenedicarboxylates and β-nitrostyrene derivatives in the presence of Iron(III) chloride afforded 1,2,3,4-tetra-substituted pyrroles in high yields. These reactions could precede via domino Micha
