1315212-91-9Relevant academic research and scientific papers
Pyrrole-assisted and easy oxidation of cyclic α-amino acid- derived diketopiperazines under mild conditions
Tian, Hua,Ermolenko, Ludmila,Gabant, Marion,Vergne, Carine,Moriou, Celine,Retailleau, Pascal,Al-Mourabit, Ali
, p. 1525 - 1533 (2011/09/14)
A new procedure for the aerobic oxidation of α-amino acids acylated by pyrrole-carboxylic acid with triplet dioxygen is introduced. The reaction is general for a variety of pyrrole-amino acid derivatives and represents a very practical and controllable method for the selective preparation of α-hydroperoxy- or α-hydroxy-α-amino acid diketopiperazines with molecular dioxygen. Furthermore, the non-catalyzed direct oxidation of amino acid derivatives at the α-position with molecular dioxygen represents a fundamental question. Copyright
