1315271-12-5

Basic information

• Product Name: N-(t-butoxycarbonyl)-D-2-bromophenyalaninal
• Synonyms: N-(t-butoxycarbonyl)-D-2-bromophenyalaninal
• CAS NO: 1315271-12-5
• Molecular Weight: 328.206
• Mol File: 1315271-12-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(t-butoxycarbonyl)-D-2-bromophenyalaninal(CAS DataBase Reference)
• NIST Chemistry Reference: N-(t-butoxycarbonyl)-D-2-bromophenyalaninal(1315271-12-5)
• EPA Substance Registry System: N-(t-butoxycarbonyl)-D-2-bromophenyalaninal(1315271-12-5)

Safety Data

• Hazardous Substances Data: 1315271-12-5(Hazardous Substances Data)

Upstream product

• 261360-76-3 N-Boc-D-2-bromophenylalanine 
• 1315271-09-0 C₁₆H₂₃BrN₂O₄ 

Downstream Products

• 1315271-23-8 (2S,3S,4R)-4-tert-butoxycarbonylamino-5-(2'-bromophenyl)-3-hydroxy-2-methylpentanoic acid 
• 1315271-31-8 (2S,3S,4R)-5-(2'-bromophenyl)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-3-hydroxy-2-methylpentanoic acid 
• 1315271-17-0 (1R,2S,3S,4'S)-[1-(2'-bromobenzyl)-2-hydroxy-4-(4'-isopropyl-2'-oxo-oxazolidin-3'-yl)-3-methyl-4-oxobutyl]carbamic acid tert-butyl ester 

Relevant articles and documents

Deglycobleomycin A6 analogues modified in the methylvalerate moiety

Previous studies have indicated that the methylvalerate subunit of bleomycin (BLM) plays an important role in facilitating DNA cleavage by BLM and deglycoBLM. Eleven methylvalerate analogues have been synthesized and incorporated into deglycoBLM congeners by the use of solid-phase synthesis. The effect of the valerate moiety in the deglycoBLM analogues has been studied by comparison with the parent deglycoBLM A5 using supercoiled DNA relaxation and sequence-selective DNA cleavage assays. All of the deglycoBLM analogues were found to effect the relaxation of the plasmid DNA. Those analogues having aromatic C4-substituents exhibited cleavage efficiency comparable to that of deglycoBLM A5. Some, but not all, of the deglycoBLM analogues were also capable of mediating sequence-selective DNA cleavage.