1315276-22-2Relevant academic research and scientific papers
Solvent-free microwave michael addition of isatin and aniline schiff base of isatin to α,β-unsaturated esters
Imanzadeh, Gholamhassan,Aghaalizadeh, Tooran,Zamanloo, Mohammadreza,Mansoori, Yagoub
experimental part, p. 616 - 620 (2012/04/23)
The rapid, simple, microwave-assisted Michael addition of isatin and aniline Schiff base of isatin to a wide variety of alkyl and aryl acrylates in the presence of, tetrabutylammonium bromide (TBAB) and 1,4-diazabicyclo[2.2.2] octane (DABCO), under solvent-free conditions, is presented. Under these conditions the addition of isatin to some of alkyl and aryl acrylates afford both related Baylis-Hillman adducts as minor products and the corresponding Michael adducts as major products. Addition of isatin to ethyl acrylate leads to produce Baylis-Hillman/Michael adduct in good yield. This system dose not work on Michael acceptors of methyl acrylate and methyl methacrylate.
