1315277-45-2

Upstream product

• 21815-91-8 3-chlorobenzo[b]thiophen-2-carbonyl chloride 
• 367-21-5 3-chloro-4-fluorophenylamine 
• 215777-89-2 2-(3-chloro-1-benzothiophen-2-yl)-4H-3,1-benzoxazin-4-one 
• 621-82-9 Cinnamic acid 

Relevant academic research and scientific papers

Synthesis and antimicrobial activity of some new 2-(3-chloro-1- benzothiophen-2-yl)-3-(substituted-phenyl)-4- (3H)-quinazolinones derivatives

3-Chloro-1-benzothiophene-2-carbonylchloride 1 reacted with anthranilic acid in pyridine to give compound 2. The main aim of the work is to study the behavior of this 4H-3,1-benzoxazin-4-one toward nitrogen nucleophiles. The compound reacted with aromatic amines, hydroxylamine hydrochloride, formamide, thioglycolic acid, thiosemicarbazide and acid chlorides to give various 3-substituted quinazolinones, respectively. The structures of all the synthesized compounds were confirmed by spectral data and have been screened for antibacterial and antifungal activity.