1315277-95-2

Upstream product

• 5470-84-8 4-benzyloxybutanal 
• 824-94-2 p-methoxybenzyl chloride 
• 575452-49-2 7-(benzyloxy)-4-hydroxyhept-1-ene 

Downstream Products

• 1234691-64-5 S-ethyl 6-benzyloxy-3-(4-methoxybenzyloxy)-1-hexanethioate 
• 1234691-65-6 S-(4-methylphenyl) 6-benzyloxy-3-(4-methoxybenzyloxy)-1-hexanethioate 
• 1234691-67-8 S-phenyl 6-benzyloxy-3-(4-methoxybenzyloxy)-1-hexanethioate 
• 1234691-68-9 S-(4-nitrophenyl) 6-benzyloxy-3-(4-methoxybenzyloxy)-1-hexanethioate 
• 1234691-45-2 1-benzyloxy-4,11-bis(4-methoxybenzyloxy)-7-undecyn-6-one 
• 1234691-48-5 1-benzyloxy-4-(4-methoxybenzyloxy)-7-dodecyn-6-one 
• 1234691-49-6 1-benzyloxy-11-(tert-butyldiphenylsilyloxy)-4-(4-methoxybenzyloxy)-7-undecyn-6-one 
• 1234691-50-9 8-benzyloxy-5-(4-methoxybenzyloxy)-1-phenyl-1-octyn-3-one 
• 1234691-51-0 8-benzyloxy-1-cyclohexyl-5-(4-methoxybenzyloxy)oct-1-yn-3-one 
• 1234691-52-1 1,10-bis(benzyloxy)-7-(4-methoxybenzyloxy)-2,2-dimethyldec-3-yn-5-one 
• 1234691-56-5 6-(3-benzyloxypropyl)-2-butyl-5,6-dihydro-4H-pyran-4-one 
• 1234691-57-6 6-(3-benzyloxypropyl)-2-[3-(tert-butyldiphenylsilyloxy)propyl]-5,6-dihydro-4H-pyran-4-one 
• 1234691-58-7 6-(3-benzyloxypropyl)-2-phenyl-5,6-dihydro-4H-pyran-4-one 
• 1234691-59-8 6-(3-benzyloxypropyl)-2-cyclohexyl-5,6-dihydro-4H-pyran-4-one 

Relevant academic research and scientific papers

A new strategy for the synthesis of substituted dihydropyrones and tetrahydropyrones via palladium-catalyzed coupling of thioesters

In this paper, we describe a new strategy for the synthesis of substituted dihydropyrones and tetrahydropyrones. By exploiting palladium-catalyzed coupling of thioesters with terminal alkynes or alkenylboronic acids, a variety of β-hydroxy ynones or enones, respectively, could be prepared in an efficient manner under mild conditions. AgOTf-promoted intramolecular oxa-conjugate cyclization of β-hydroxy ynones provided 2,6-substituted dihydropyrones in excellent yields. On the other hand, acid-catalyzed cyclization of β-hydroxy enones caused racemization of the product 2,6-substituted tetrahydropyrones due to its reversible nature. Eventually, stereoselective hydrogenation of substituted dihydropyrones was found to be a solid and efficient approach for the synthesis of 2,6-cis-substituted tetrahydropyrone derivatives.