13153-63-4Relevant academic research and scientific papers
Methyl aryl thioether compound, and synthetic method and applications thereof
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Paragraph 0122; 0123; 0124, (2017/07/21)
The invention discloses a methyl aryl thioether compound represented by formula 2, and a synthetic method and applications thereof. According to the synthetic method, in a reaction solvent, an aryl halide or an aromatic halide, dimethyl carbonate, and potassium thioacetate are taken as reaction raw materials, reaction is carried out in the presence of metal palladium catalyst under the action of a ligand and an alkali so as to obtain the methyl aryl thioether compound. The reaction conditions of the synthetic method are mild; the raw materials are cheap and easily available; reaction operation is simple; yield is relatively high. The methyl aryl thioether compound can be used for providing skeleton structures for the synthesis of a plurality of natural products and medicines, and can be widely applied in industrialized large-scale production.
FLUORESCENT NUCLEOSIDE ANALOGUES. SYNTHESIS OF FLUORESCENT PYRIDOPURINES, AND THEIR CORRESPONDING RIBOSIDES
Odijk, W. M.,Koomen, G. J.
, p. 1893 - 1904 (2007/10/02)
Fluorescent pyridopurines can in principle be obtained via Michael-addition of a suitable anion of a purine derivative to an acetylenic ester, followed by based-catalyzed cyclization, as depicted in Scheme II. 6-Substituted purine-derivatives are obtained via nucleophilic substitution on 6-chloro- and 6-methylsulfonylpurine (8a and 8b).In the presence of methyl propiolate and sodium methoxide, before cyclization, two consecutive Michael-additions take place, leading to 13 and 14.With substituted acetylenic esters, cyclization occurs after one Michael-addition. Michael-additions with ethylenic esters did not lead to expected cyclization products, except in cases where oxidation took place.For the conversion of the pyridopurines into the corresponding ribosides protection against nucleophilic attack was necessary.
