1315318-92-3Relevant academic research and scientific papers
Total synthesis of potent antitumor macrolide (-)-zampanolide: An oxidative intramolecular cyclization-based strategy
Ghosh, Arun K.,Cheng, Xu,Bai, Ruoli,Hamel, Ernest
, p. 4130 - 4139 (2012/10/08)
A detailed account of the enantioselective total synthesis of (-)-zampanolide, a macrolide marine natural product with high anticancer activity, is described. For the synthesis of the 4-methylenetetrahydropyran unit of (-)-zampanolide, we initially relied
Enantioselective total synthesis of (-)-zampanolide, a potent microtubule-stabilizing agent
Ghosh, Arun K.,Cheng, Xu
, p. 4108 - 4111 (2011/10/04)
An enantioselective total synthesis of zampanolide has been accomplished using a novel DDQ/Bronsted acid promoted cyclization as the key reaction. The synthesis features cross-metathesis to construct the trisubstituted olefin and a ring-closing metathesis
