131533-69-2

Upstream product

• 1068-52-6 sodium 2-bromoacetate 
• 2746-25-0 p-Methoxybenzyl bromide 
• 110289-28-6 3β-t-butyloxycarbonylamino-4β-[2-(furan-2-yl)ethyl]azetidin-2-one 
• 99333-65-0 1-benzyl-3β-((S)-2-oxo-4-phenyloxazolidin-3-yl)-4β-[2-(2-furyl)ethyl]azetidin-2-one 
• 110289-29-7 (3S,4R)-3-amino-4-[2-(furan-2-yl)ethyl]azetidin-2-one 

Downstream Products

• 132109-17-2 (6R,7S)-7-tert-Butoxycarbonylamino-3-hydroxy-8-oxo-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxy-benzyl ester 
• 131533-91-0 [(3S,4R)-3-tert-Butoxycarbonylamino-2-oxo-4-(2-phenylsulfanylcarbonyl-ethyl)-azetidin-1-yl]-acetic acid 4-methoxy-benzyl ester 
• 131533-79-4 3-[(2R,3S)-3-tert-Butoxycarbonylamino-1-(4-methoxy-benzyloxycarbonylmethyl)-4-oxo-azetidin-2-yl]-propionic acid 

Relevant academic research and scientific papers

Synthesis of carbacephem antibiotics: Synthesis via Dieckmann reaction using phenyl esters to direct the regioselectivity of the cyclization

β-Ketoesters useful for elaboration to carbacephems were synthesized from a variety of enantiomerically pure diesters. Use of phenyl esters to direct the regioselectivity was demonstrated.