1315340-19-2Relevant articles and documents
Organocatalytic asymmetric Michael-type/wittig reaction of phosphorus ylides: Synthesis of chiral α-methylene-δ-ketoesters
Lin, Aijun,Wang, Junying,Mao, Haibin,Ge, Huiming,Tan, Renxiang,Zhu, Chengjian,Cheng, Yixiang
, p. 4176 - 4179 (2011/10/02)
An asymmetric Michael-type reaction of phosphorus ylides and α,β-unsaturated ketones under the catalysis of a chiral ion pair catalyst has been described. The ion pair catalyst containing a chiral counteranion was prepared by simply mixing 9-amino-(9-deoxy)-epi-quinine with l-N-Boc-proline. The optically active α-methylene-δ-ketoesters could be obtained with good to excellent enantioselectivities (up to 95% ee) under mild reaction conditions.
