1315355-93-1 Usage
Uses
NG 25 inhibits TGF-beta-activated kinase 1 (TAK1). It also inhibits LYN, mitogen-activated protein kinase (MAP4K2) and Abl kinase activity.
Biochem/physiol Actions
NG25 is potent multiple kinase inhibitor belonging to type II kinase inhibitors class that binds to kinase ATP binding pocket at not ready to catalyze conformation. NG25 is used as a potent dual inhibitor of TAK1 (TGFβ-Activated Kinase 1, MAP3K7) and MAP4K2 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2; GCK) kinases. NG25 inhibits the activation of IKKa/IKKb and prevents the secretion of type 1 IFNs by TLR2 and TLR9 agonist.
Check Digit Verification of cas no
The CAS Registry Mumber 1315355-93-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,1,5,3,5 and 5 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1315355-93:
(9*1)+(8*3)+(7*1)+(6*5)+(5*3)+(4*5)+(3*5)+(2*9)+(1*3)=141
141 % 10 = 1
So 1315355-93-1 is a valid CAS Registry Number.
1315355-93-1Relevant articles and documents
Discovery of type II inhibitors of tgfβ-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2)
Tan, Li,Nomanbhoy, Tyzoon,Gurbani, Deepak,Patricelli, Matthew,Hunter, John,Geng, Jiefei,Herhaus, Lina,Zhang, Jianming,Pauls, Eduardo,Ham, Youngjin,Choi, Hwan Geun,Xie, Ting,Deng, Xianming,Buhrlage, Sara J.,Sim, Taebo,Cohen, Philip,Sapkota, Gopal,Westover, Kenneth D.,Gray, Nathanael S.
, p. 183 - 196 (2015/03/04)
We developed a pharmacophore model for type II inhibitors that was used to guide the construction of a library of kinase inhibitors. Kinome-wide selectivity profiling of the library resulted in the identification of a series of 4-substituted 1H-pyrrolo[2,
