1315461-05-2Relevant academic research and scientific papers
Synthesis and local anaesthetic activities of 2-aminothiazole/thiadiazole analogues of lidocaine
Badiger, Naveen P.,Khan, Ashraf,Kalashetti,Khazi
, p. 1544 - 1549 (2012/11/07)
Various 2-aminothiazole and 2-aminothiadiazole derivatives viz N-[4-(2-Chloro-4-fluoro-phenyl)-thiazol-2-yl]-2-substituted acetamides (3a, 4a, 5a) and N-[5-(4-substituted aryl)-[1,3,4]thiadiazol-2-yl]-2-acetamides (3b, 3c, 4b, 4c, 5b, 5c) were synthesized from their corresponding properly substituted 2-aminothiazoles and 2-aminothiadiazoles. Structures of all the newly synthesized compounds were established by analytical and spectral data. Synthesized compounds were screened for their local anaesthetic activity using the rat sciatic nerve model. Springer Science+Business Media, LLC 2011.
