1315465-29-2

Upstream product

• 39684-80-5 2-(tert-butoxycarbonylamino)ethyl bromide 
• 1315465-27-0 2-(4-bromo-2-(trifluoromethyl)phenoxy)ethanamine 
• 1315465-26-9 1-(2-azidoethoxy)-4-bromo-2-(trifluoromethyl)benzene 
• 1315465-25-8 2-(4-bromo-2-(trifluoromethyl)phenoxy)ethyl methanesulfonate 
• 1104382-36-6 2-(4-bromo-2-(trifluoromethyl)phenoxy)-ethanol 
• 50824-04-9 4-bromo-2-(trifluoromethyl)phenol 
• 1315465-28-1 tert-butyl 2-(4-bromo-2-(trifluoromethyl)phenoxy)ethylcarbamate 
• 73183-34-3 bis(pinacol)diborane 

Downstream Products

• 1315465-31-6 tert-butyl 2-(4-(4-cyano-1-methyl-1H-[1,2,3]triazolo[4,5-c]pyridin-6-yl)-2-(trifluoromethyl)phenoxy)ethylcarbamate 
• 1315465-32-7 6-(4-(2-aminoethoxy)-3-(trifluoromethyl)phenyl)-1-methyl-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile 
• 1315464-53-9 N-(2-(4-(4-cyano-1-methyl-1H-[1,2,3]triazolo[4,5-c]pyridin-6-yl)-2-(trifluoromethyl)phenoxy)ethyl)acetamide 
• 1315465-30-5 tert-butyl 2-(4-(5-amino-6-cyano-4-(methylamino)pyridin-2-yl)-2-(trifluoromethyl)phenoxy)ethylcarbamate 

Relevant academic research and scientific papers

MULTICYCLIC COMPOUNDS AND METHODS OF USING SAME

The invention generally relates to compounds represented by Structural Formula I: or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of

1H-[1,2,3]TRIAZOLO[4,5-c]PYRIDINE-4-CARBONITRILE DERIVATIVES

The invention relates to 1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile derived Cathepsin S inhibitors of Formula (I), wherein R1 is H or (C1-3)alkyl; R2 is halogen or (C1-4)alkyl, optionally substituted with one or more halogens; n is 1 -3; X is O or CH2; U, V and W are CH; or one of U, V and W is N; Y is a group capable of interacting with the Sn....S2 substites of the active site of Cathepsin S; or a pharmaceutically acceptable salt thereof, to pharmaceutical compositions comprising the same as well as to the use of these derivatives for the preparation of a medicament for the treatment of cathepsin S related diseases such as atherosclerosis, obesity, inflammation and immune disorders, such as rheumatoid arthritis, psoriasis, cancer, and chronic pain, such as neuropathic pain.