1315469-40-9Relevant academic research and scientific papers
Discovery of novel pyrimidine and malonamide derivatives as TGR5 agonists
Park, Eun Ju,Ahn, Young Gil,Jung, Seung Hyun,Bang, Hyo Jeong,Kim, Mira,Hong, Dong Jin,Kim, Jisook,Suh, Kwee Hyun,Kim, Young Jin,Kim, Doran,Kim, Eun-Yeong,Lee, Kiho,Min, Kyung Hoon
, p. 4271 - 4275 (2014)
Takeda G-protein-coupled receptor 5 (TGR5) is a promising molecular target for metabolic diseases. A series of 4-(2,5-dichlorophenoxy)pyrimidine and cyclopropylmalonamide derivatives were synthesized as potent agonists of TGR5 based on a bioisosteric repl
4-PHENOXY-NICOTINAMIDE OR 4-PHENOXY-PYRIMIDINE-5-CARBOXAMIDE COMPOUNDS
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Page/Page column 50, (2011/08/04)
This invention relates to novel phenyl amide or pyridyl amide derivatives of the formula wherein A1, A2, B1, B2 and R1 to R11 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are GPBAR1 agonists and can be used as medicaments for the treatment of diseases such as type II diabetes.
4-PHENOXY-NICOTINAMIDE OR 4-PHENOXY-PYRIMIDINE-5-CARBOXAMIDE COMPOUNDS
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Page/Page column 107, (2011/08/08)
This invention relates to novel phenyl amide or pyridyl amide derivatives of the formula (I), wherein A1, A2, B1, B2 and R1 to R11 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are GPBAR1 agonists and can be used as medicaments for the treatment of diseases such as type II diabetes.
