1315477-20-3Relevant academic research and scientific papers
A one-pot approach to Δ2-isoxazolines from ketones and arylacetylenes
Schmidt, Elena Yu.,Tatarinova, Inna V.,Ivanova, Elena V.,Zorina, Nadezhda V.,Ushakov, Igor A.,Trofimov, Boris A.
supporting information, p. 104 - 107 (2013/03/28)
The sequential reaction of ketones with arylacetylenes and hydroxylamine in the presence of KOBut/DMSO followed by the treatment of the reaction mixture with H2O and KOH leads to Δ2-isoxazolines in up to 88% yield.
Transition metal-free stereoselective α-vinylation of cyclic ketones with arylacetylenes in the superbasic catalytic triad potassium hydroxide/tert-butyl alcohol/dimethyl sulfoxide
Trofimov, Boris A.,Schmidt, Elena Yu.,Zorina, Nadezhda V.,Ivanova, Elena V.,Ushakov, Igor A.,Mikhaleva, Al'Bina I.
supporting information; experimental part, p. 1813 - 1818 (2012/08/13)
A stereoselective α-vinylation of cycloaliphatic ketones with arylacetylenes under the transition metal-free conditions has been developed. The reaction is promoted by the superbasic catalytic triad potassium hydroxide/tert-butyl alcohol/dimethyl sulfoxide (80-110 °C, 1-2 h) to afford mainly (E)-β,γ-ethylenic ketones, their (E)-α,β-isomers being minor products, in up to 83% total yield. Copyright
