131550-33-9

Upstream product

• 131550-35-1 2-Cyclohexyl-1-((2S,3R)-3-isobutyl-oxiranyl)-ethanol 
• 131550-32-8 cyclohexylmethyllithium 
• 35166-78-0 cyclohexylmethyl magnesium bromide 
• 145475-58-7 (2R,3S)-3-Isobutyl-oxirane-2-carboxylic acid ethyl ester 
• 181025-90-1 (2S,3S)-3-Acetoxy-2-bromo-5-methyl-hexanoic acid ethyl ester 
• 181025-89-8 (2R,3S)-5-Methyl-2,3-dihydroxyhexanoate ethyl ester 
• 181025-94-5 (2S,3S)-2-Bromo-3-hydroxy-5-methyl-hexanoic acid ethyl ester 
• 34993-63-0 ethyl (E)-5-methylhex-2-enoate 
• 505029-44-7 (2R,3S)-2,3-epoxy-5-methylhexanol 

Downstream Products

• 131550-36-2 (4R,5R)-4-Cyclohexylmethyl-5-((S)-1-hydroxy-3-methyl-butyl)-oxazolidin-2-one 
• 117161-13-4 (4S,5R)-4-cyclohexylmethyl-5-<(1'S)-1'-hydroxy-3-methylbutyl>oxazolidin-2-one 
• 181025-91-2 Benzyl-[(S)-2-cyclohexyl-1-((2S,3S)-3-isobutyl-oxiranyl)-ethyl]-amine 
• 131451-97-3 (4S,5R)-3-Benzyl-4-cyclohexylmethyl-5-<(S)-(1-hydroxy-3-methyl)butyl>oxazolidin-2-one 

Relevant academic research and scientific papers

Asymmetric synthesis of the Abbott amino dihydroxyethylene dipeptide isostere subunit

The aminodiol 1b, a N-benzyl protected form of the Abbott dipeptide isostere 1a is prepared, starting from an appropriate α,β-unsaturated ester, involving an asymmetric dihydroxylation and a rearrangement of an intermediate anti α,β-aminoepoxide.

A Versatile, Efficient Synthesis of (-)-(2S, 3R, 4S)-2-Amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane, The Abbott Pseudodipeptidyl Insert

An economic construction (6 steps, 36percent yield) of a valuable peptide analog subunit, the Abbott pseudodipeptidyl insert (-)-(2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane (1), has been developed.