1315512-61-8

Basic information

• Product Name: 5-(3-Chloropropoxy)-4-methoxy-2-nitrobenzonitrile
• Synonyms: 5-(3-Chloropropoxy)-4-methoxy-2-nitrobenzonitrile;5-(3-chlorpropoxy)-4-Methoxy-2-nitrobenzonitrile
• CAS NO: 1315512-61-8
• Molecular Formula: C11H11ClN2O4
• Molecular Weight: 270.66904
• Mol File: 1315512-61-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 466.2±45.0 °C(Predicted)
• Appearance: /
• Density: 1.34
• CAS DataBase Reference: 5-(3-Chloropropoxy)-4-methoxy-2-nitrobenzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(3-Chloropropoxy)-4-methoxy-2-nitrobenzonitrile(1315512-61-8)
• EPA Substance Registry System: 5-(3-Chloropropoxy)-4-methoxy-2-nitrobenzonitrile(1315512-61-8)

Safety Data

• Hazardous Substances Data: 1315512-61-8(Hazardous Substances Data)

Usage

General Description

5-(3-Chloropropoxy)-4-methoxy-2-nitrobenzonitrile is a chemical compound with the molecular formula C11H10ClN2O4. It is a nitrile derivative with a nitro group and a methoxy group attached to a benzene ring, as well as a chloropropoxy group attached to the benzene ring. 5-(3-Chloropropoxy)-4-methoxy-2-nitrobenzonitrile is commonly used in the synthesis of pharmaceuticals and agrochemicals due to its potential biological activity. It is important to handle this chemical with caution, as it may be hazardous if not properly managed. Additionally, its potential environmental impact should be considered when using and disposing of it.

Upstream product

• 52805-46-6 2-methoxy-5-cyanophenol 
• 929683-54-5 3-(3-chloropropoxy)-4-methoxybenzaldehyde 
• 621-59-0 isovanillin 

Downstream Products

• 199327-59-8 4-chloro-7-methoxy-6-(3-morpholinopropoxy)quinazoline 
• 1437310-67-2 N-(3-ethynylphenyl)-6-(3-chloropropoxy)-7-methoxyquinazolin-4-amine 
• 1259017-73-6 N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-(3-chloropropoxy)-7-methoxyquina-zolin-4-amine 

Relevant articles and documents

Design, synthesis, and biological evaluation of quinazoline derivatives containing piperazine moieties as antitumor agents

A series of novel quinazoline derivatives containing piperazine analogs are synthesized via substitution reactions with 6,7-disubstituted 4-chloroquinazoline and benzyl piperazine (amido piperazine). Potent antiproliferative activities are observed against A549, HepG2, K562, and PC-3 with N-(3-chlorophenyl)-2-(4-(7-methoxy-6-(3-morpholino-propoxy)quinazoline-4-yl)piperazine-1-yl)acetamidename C9 showing excellent activity. This active derivative was screened for cell migration ability, proliferation effects, and apoptosis against A549 and PC-3 cells, with the result showing biological activity almost equal to that of the control gefitinib.

4-heterocycle substituted quinazoline derivative and preparation method and application thereof

The invention discloses a 4-heterocycle substituted quinazoline derivative and a preparation method and application thereof. The compound has a structure expressed by a general formula (I): (please see the specification for the formula), in the formula, R1 and R2 are independently selected from hydrogen, a saturated or unsaturated five-membered heterocycle, or a saturated or unsaturated six-membered heterocycle, and n is an integer from 1 to 6; X is NH, O or S; and a heterocycle A is independently selected from pyridine or substituted pyridine, pyrimidine or substituted pyrimidine, pyrazol orsubstituted pyrazol, pyrazine or substituted pyrazine, thiazole or substituted thiazole, or benzothiazole or substituted benzothiazole. The compound or pharmaceutically formable salts thereof have aninhibitory effect on proliferation of tumor cells and can be used for preparing drugs for treatment of glioma, non-small cell lung cancer, breast cancer, colon cancer, stomach cancer, liver cancer andcervical cancer diseases.