1315563-07-5Relevant academic research and scientific papers
Synthesis of a novel series of highly functionalized Baylis-Hillman adducts of artemisinin with potent anticancer activity
Goswami, Abhishek,Saikia, Partha P.,Saikia, Bishwajit,Barua, Nabin C.,Saxena, Ajit K.,Suri, Nitasha,Sharma, Madhunika,Baishya, Gakul
, p. 4221 - 4224 (2013)
A novel series of densely functionalized derivatives of artemisinin have been synthesized using Baylis-Hillman reaction and their further applicability has been demonstrated. The in vitro anticancer activity of these adducts against a panel of human cancer cell lines is summarized. Compound 10 (% GI of 100 against colon colo-205; % GI of 85 against Lung A-549), 7b (% GI of 78 against prostrate PC-3) and 9a, 9b (% GI of 71 against prostrate PC-3) were especially potent in inhibiting the growth of certain human cancer cell lines and were comparable to that of clinically used anticancer drugs. These newly synthesized compounds can be further utilized as potential precursor for the synthesis of libraries of new artemisinin analogs including dimer.
NEW SERIES OF ARTEMISININ DERIVATIVES AND PROCESS FOR PREPARATION THEREOF
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, (2013/03/26)
This invention relates to the synthesis of certain novel Baylis-Hillman adducts of artremisinin derived aldehyde 2[10′β-deoxoartemisininyl]-ethanal. The capabilities of introduction of three functional groups into a molecule in one step using Baylis-Hillman reaction encouraged us to synthesize some highly functionalized derivatives of artemisinin. These highly functionalized artemisinin derivatives embodied in this document are found to be active against various cancer cell-lines
A NEW SERIES OF ARTEMISININ DERIVATIVES AND PROCESS FOR PREPARATION THEREOF
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, (2011/08/08)
This invention relates to the synthesis of certain novel Baylis-Hillman adducts of artremisinin derived aldehyde 2-[10'β-deoxoartemisininyl]-ethanal. The capabilities of introduction of three functional groups into a molecule in one step using Baylis-Hillman reaction encouraged us to synthesize some highly functionalized derivatives of artemisinin. These highly functionalized artemisinin derivatives embodied in this document are found to be active against various cancer cell-lines
