131557-35-2

Upstream product

• 18234-50-9 (E)-1-(thiophen-2-yl)-3-(2-hydroxyphenyl)prop-2-en-1-one 
• 88-15-3 2-Acetylthiophene 
• 90-02-8 salicylaldehyde 

Downstream Products

• 871319-16-3 C₂₀H₁₆N₂O₂S 
• 131557-39-6 C₁₅H₁₄N₂O₂S 
• 1366019-70-6 C₁₅H₁₂N₂O₂S 
• 1366019-98-8 C₂₀H₁₄N₂O₂S 
• 1262757-94-7 C₁₃H₁₁N₃O₂S 
• 1366020-25-8 C₁₃H₉N₃O₂S 
• 187173-74-6 2-(5-Thiophen-2-yl-2H-pyrazol-3-yl)-phenol 

Relevant academic research and scientific papers

Synthesis of 3,5-disubstituted pyrazoles and their derivatives

2-Acetylthiophene condenses with different aromatic aldehyde in ethanol in the presence of aqueous NaOH to give 1-(2′-thienyl)-3-(substituted phenyl)-2-propen-1-one (Ia-e) which reacts with hydrazine hydrate in ethanol to give pyrazoline (IIa-e) and also treated with DMSO in presence of catalytic amount of iodine to give pyrazole (II′a-e) Similarly, 1-phenyl pyrazoline (IIIa-e) treated with DMSO/I2 to give 1-phenyl pyrazole(III′a- e), 1-(2,4-dinitro phenyl) pyrazoline (IVa-e) treated with DMSO/I2 to give 1-(2,4-dinitro phenyl) pyrazole(IV′a-e), 1-carboxamido pyrazoline (Va-e) treated with DMSO/I2 to give 1-carboxamido pyrazole (V′a-e), 1-acetyl pyrazoline (VIa-e) treated with DMSO/I2 to give 1-acetyl pyrazole (VI′a-e), 1-benzoyl pyrazoline (VIIa-e) treated with DMSO/I2 to give 1-benzoyl pyrazole (VII′a-e) and 1-nitroso pyrazoline (VIIIa-e) treated with DMSO/I2 to give 1-nitroso pyrazole (VIII′a-e). Characterization and structural elucidation was carried out on the basis of melting points determination, analytical and spectral studies.

Structure-activity relationship studies of novel pyrazolo[1,5-c][1,3]benzoxazines: Synthesis and benzodiazepine receptor affinity

Some 2-arylpyrazolo[1,5-c][1,3]benzoxazin-5-ones 1 and 5 oxopyrazolo[1,5-c][1,3]benzoxazin-2-carboxylates 2 were prepared and biologically evaluated for their binding at benzodiazepine receptor (BZR) in rat cortical membranes. Structure-activity relations