1315577-24-2Relevant academic research and scientific papers
General method for the synthesis of salicylic acids from phenols through palladium-catalyzed silanol-directed C-H carboxylation
Wang, Yang,Gevorgyan, Vladimir
supporting information, p. 2255 - 2259 (2015/02/19)
A silanol-directed, palladium-catalyzed C-H carboxylation reaction of phenols to give salicylic acids has been developed. This method features high efficiency and selectivity, and excellent functional-group tolerance. The generality of this method was demonstrated by the carboxylation of estrone and by the synthesis of an unsymmetrically o,o′-disubstituted phenolic compound through two sequential C-H functionalization processes.
Silanol: A traceless directing group for Pd-catalyzed o -alkenylation of phenols
Huang, Chunhui,Chattopadhyay, Buddhadeb,Gevorgyan, Vladimir
, p. 12406 - 12409 (2011/10/02)
A silanol-directed, Pd(II)-catalyzed C-H alkenylation of phenols is reported. This work features silanol, as a novel traceless directing group, and a directed o-C-H alkenylation of phenols. This new method allows for efficient synthesis of diverse alkenylated phenols, including an estrone derivative.
