Cas 1315585-75-1,C29H29FN8O3S

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Check Digit Verification of cas no

The CAS Registry Mumber 1315585-75-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,1,5,5,8 and 5 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1315585-75:
(9*1)+(8*3)+(7*1)+(6*5)+(5*5)+(4*8)+(3*5)+(2*7)+(1*5)=161
161 % 10 = 1
So 1315585-75-1 is a valid CAS Registry Number.

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1315585-75-1Relevant academic research and scientific papers

Novel series of pyrrolotriazine analogs as highly potent pan-Aurora kinase inhibitors

Abraham, Sunny,Hadd, Michael J.,Tran, Lan,Vickers, Troy,Sindac, Janice,Milanov, Zdravko V.,Holladay, Mark W.,Bhagwat, Shripad S.,Hua, Helen,Ford Pulido, Julia M.,Cramer, Merryl D.,Gitnick, Dana,James, Joyce,Dao, Alan,Belli, Barbara,Armstrong, Robert C.,Treiber, Daniel K.,Liu, Gang

scheme or table, p. 5296 - 5300 (2011/10/08)

The synthesis and SAR for a novel series of pyrrolotriazines as pan-Aurora kinase inhibitors are described. Optimization of the cyclopropane carboxamide terminus of lead compound 1 resulted in analogs with high cellular activity and improved rat PK profiles. Notably, compound 17l demonstrated tumor growth inhibition in a mouse xenograft model.

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