13156-33-7

Upstream product

• 123-91-1 1,4-dioxane 
• 3017-70-7 2-bromo-3-methylbut-2-ene 
• 110-70-3 N,N`-dimethylethylenediamine 
• 55-21-0 benzamide 
• 870-63-3 prenyl bromide 
• 6282-02-6 N-(hydroxymethyl)benzamide 
• 13157-50-1 6,6-dimethyl-2-phenyl-5,6-dihydro-4H-[1,3]oxazine 

Downstream Products

• 133523-76-9 N-(3-methyl-2-butenyl)thiobenzamide 
• 133523-86-1 5-(1-Methyl-1-phenylselanyl-ethyl)-2-phenyl-4,5-dihydro-thiazole 
• 133523-91-8 5-Isopropyl-2-phenyl-2-thiazoline 
• 133523-67-8 5-(1-Bromo-1-methyl-ethyl)-2-phenyl-4,5-dihydro-thiazole 
• 133523-68-9 5-Isopropenyl-2-phenyl-4,5-dihydro-thiazole 
• 133523-90-7 5,6-Dihydro-6,6-dimethyl-2-phenyl-4H-1,3-thiazine 

Relevant academic research and scientific papers

Organocatalytic Synthesis of Oxazolines and Dihydrooxazines from Allyl-Amides: Bypassing the Inherent Regioselectivity of the Cyclization

A selective and efficient methodology for the construction of either oxazolines or dihydrooxazines from the corresponding allyl-amides is reported. Bypassing the inherent selectivity of the cyclization and depending on the substitution pattern of the substrate, a selective epoxidation-cyclization was developed leading to either the five-membered or the six-membered ring, upon simple and complementary reaction conditions. The cyclization products were obtained in good to excellent yields and high selectivities. (Figure presented.).

Copper-catalyzed formation of carbon-heteroatom and carbon-carbon bonds

The present invention relates to copper-catalyzed carbon-heteroatom and carbon-carbon bond-forming methods. In certain embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-nitrogen bond between the nitrogen atom of an amide or amine moiety and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. In additional embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-nitrogen bond between a nitrogen atom of an acyl hydrazine and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. In other embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-nitrogen bond between the nitrogen atom of a nitrogen-containing heteroaromatic, e.g., indole, pyrazole, and indazole, and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. In certain embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-oxygen bond between the oxygen atom of an alcohol and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. The present invention also relates to copper-catalyzed methods of forming a carbon-carbon bond between a reactant comprising a nucleophilic carbon atom, e.g., an enolate or malonate anion, and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. Importantly, all the methods of the present invention are relatively inexpensive to practice due to the low cost of the copper comprised by the catalysts.