1315613-65-0

Basic information

• Product Name: (2S,3R)-methyl 2-amino-4,4-bis(diethoxyphosphoryl)-3-(4-nitrophenyl)butanoate
• CAS NO: 1315613-65-0
• Molecular Weight: 510.418
• Mol File: 1315613-65-0.mol

Chemical Properties

• CAS DataBase Reference: (2S,3R)-methyl 2-amino-4,4-bis(diethoxyphosphoryl)-3-(4-nitrophenyl)butanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,3R)-methyl 2-amino-4,4-bis(diethoxyphosphoryl)-3-(4-nitrophenyl)butanoate(1315613-65-0)
• EPA Substance Registry System: (2S,3R)-methyl 2-amino-4,4-bis(diethoxyphosphoryl)-3-(4-nitrophenyl)butanoate(1315613-65-0)

Safety Data

• Hazardous Substances Data: 1315613-65-0(Hazardous Substances Data)

Upstream product

• 555-16-8 4-nitrobenzaldehdye 
• 53359-85-6 tetraethyl 2-(4-nitrophenyl)ethene-1,1-diyldiphosphonate 
• 1660-94-2 Tetraethyl methylenediphosphonate 

Relevant articles and documents

A Facile Cu(I)/TF-BiphamPhos-catalyzed asymmetric approach to unnatural α-amino acid derivatives containing gem-bisphosphonates

A novel catalytic asymmetric Michael addition of azomethine ylide with β-substituted alkylidene bisphosphates was realized in the presence of a chiral copper(I)/TF-BiphamPhos complex. The present system provides a unique and facile access to enantioenriched unnatural α-amino acid derivatives containing gem-bisphosphonates (gem-BPs) in high yields with excellent diastereoselectivities and enantioselectivities. Subsequent transformations lead to the expedient preparation of biologically active unnatural α-amino acid derivatives containing BPs and bisphosphonic acids without loss of diastereo- and enantiomeric excess.