131575-71-8

Upstream product

• 882-33-7 diphenyldisulfane 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 118199-01-2 2,2-dibromo-1-(3,4-dimethoxyphenyl)ethene 
• 4302-52-7 4-ethynylveratrole 
• 131575-69-4 1-bromo-1-(3,4-dimethoxyphenyl)-2-phenylsulphonylethene 

Downstream Products

• 131575-74-1 (2S,3R)-2-[(E)-2-Benzenesulfonyl-1-(3,4-dimethoxy-phenyl)-vinyloxymethyl]-3-phenyl-oxirane 
• 131575-73-0 (2S,3R)-2-[(Z)-1-Benzenesulfonyl-2-(3,4-dimethoxy-phenyl)-vinyloxymethyl]-3-phenyl-oxirane 
• 131576-04-0 (E)-(R)-4-(3,4-Dimethoxy-phenyl)-2-((S)-methoxy-phenyl-methyl)-but-3-en-1-ol 
• 131575-86-5 (3R,4S)-1-(3,4-Dimethoxy-phenyl)-4-hydroxy-3-hydroxymethyl-4-phenyl-butan-1-one 
• 131575-89-8 (R)-4-(3,4-Dimethoxy-phenyl)-2-((S)-methoxymethoxy-phenyl-methyl)-but-3-yn-1-ol 
• 131575-88-7 (3R,4S)-1-(3,4-Dimethoxy-phenyl)-3-hydroxymethyl-4-methoxymethoxy-4-phenyl-butan-1-one 
• 131576-03-9 (E)-(R)-4-(3,4-Dimethoxy-phenyl)-2-((S)-phenyl-phenylsulfanylmethoxy-methyl)-but-3-en-1-ol 
• 131575-87-6 Carbonic acid (1S,2R)-4-(3,4-dimethoxy-phenyl)-2-hydroxymethyl-4-oxo-1-phenyl-butyl ester ethyl ester 
• 131576-02-8 (2R,4R)-2-(3,4-Dimethoxy-phenyl)-4-((S)-phenyl-phenylsulfanylmethoxy-methyl)-tetrahydro-furan 
• 131575-90-1 (3R,4S)-1-(3,4-Dimethoxy-phenyl)-3-hydroxymethyl-4-phenyl-4-phenylsulfanylmethoxy-butan-1-one 
• 131575-77-4 (4R,αS)-2-(3,4-dimethoxyphenyl)-4-(α-hydroxybenzyl)-3-phenylsulphonyl-4,5-dihydrofuran 
• 131575-94-5 (2S,3S,4R,αS)-2-(3,4-dimethoxyphenyl)-3-phenylsulphonyl-4-(α-hydroxybenzyl)tetrahydrofuran 
• 131575-80-9 (4R,αS)-2-(3,4-dimethoxyphenyl)-4-(α-methoxymethoxybenzyl)-3-phenylsulphonyl-4,5-dihydrofuran 
• 131575-82-1 (4R,αS)-2-(3,4-dimethoxyphenyl)-4-(α-methylthiomethoxybenzyl)-3-phenylsulphonyl-4,5-dihydrofuran 

Relevant academic research and scientific papers

Copper-catalyzed regioselective synthesis of (E)-β-fluorovinyl sulfones

Organofluorine compounds are finding increasing application in a variety of fields such as pharmaceutical, agrochemical, and material sciences. However, given the scarcity of fluorine-containing natural products, advancement in this area depends almost entirely on the development of new synthetic methodologies. In this article, we present the synthesis of a series of previously undescribed (E)-β-fluorovinyl sulfones via a simple copper-catalyzed addition of hydrogen fluoride to alkynyl sulfone starting materials in varying yields and E/Z selectivities. The hydrogenation of these products was also explored and compared with the hydrogenation of the related Z isomers. These new products may find interesting applications, given the versatility of vinyl sulfones in chemical synthesis and the unique properties of vinyl fluorides in biological settings.

Approaches to 2,6-Diaryl-3,7-DioxabicycloOctane Lignans via Asymmetric Synthesis of Dihydro- and Tetrahydro-furan Derivatives

Cyclisation of chiral non-racemic phenylsulphonylvinyl epoxy ethers, produced using the Sharpless epoxidation reaction, has been used to prepare a series of enantiomerically enriched 2-aryl-4-(α-hydroxybenzyl)-4,5-dihydrofuran derivatives.Reduction of these compounds using triethylsilane and BF3-diethyl ether gave the corresponding tetrahydrofuran derivatives stereoselectively.Attempts to convert either the dihydro- or tetrahydro-furan derivatives into lignans belonging to the 2,6-diaryl-3,7-dioxabicyclooctane series so far proved unsuccessful.