131589-05-4Relevant academic research and scientific papers
Anticancer Agents, 15. Squaric Acid Diethyl Ester: A New Coupling Reagent for the Formation of Drug Biopolymer Conjugates. Synthesis of Squaric Acid Ester Amides and Diamides
Tietze, Lutz F.,Arlt, Michael,Beller, Matthias,Gluesenkamp, Karl-Heinz,Jaehde, Eckhard,Rajewsky, Manfred F.
, p. 1215 - 1221 (2007/10/02)
Reaction of squaric acid diethyl ester (1) with a slight excess of a primary or secondary amine 2 in ethanol, dichloromethane or aqueous buffer (pH 7) at 20 deg C for 0.3 - 12 h gives the squaric acid amide esters 3 in mostly excellent yields.Treatment of
