13159-73-4

Usage

Uses

Used in Organic Synthesis:
N-(2-Hydroxybenzyl)-4-nitroaniline is used as a starting material in organic synthesis for the preparation of various organic compounds. Its unique structure allows for versatile chemical reactions, making it a valuable component in the synthesis of a wide range of products.
Used in Research:
In research settings, N-(2-Hydroxybenzyl)-4-nitroaniline serves as a key compound for studying chemical reactions and exploring new synthetic pathways. Its reactivity and structural features contribute to the advancement of chemical knowledge and the development of novel methodologies.
Used in Dye Industry:
Due to its aromatic nature and ability to participate in various chemical reactions, N-(2-Hydroxybenzyl)-4-nitroaniline is used as a dye precursor in the dye industry. Its potential to create a spectrum of colors makes it a promising candidate for the development of new dyes and pigments.
Used in Pharmaceutical Industry:
N-(2-Hydroxybenzyl)-4-nitroaniline has demonstrated potential applications in the pharmaceutical industry, particularly in the development of novel drugs and pharmaceutical products. Its chemical properties and reactivity make it a candidate for the creation of new therapeutic agents and formulations.

InChI:InChI=1/C13H12N2O3/c16-13-4-2-1-3-10(13)9-14-11-5-7-12(8-6-11)15(17)18/h1-8,14,16H,9H2

Upstream product

• 90-01-7 salicylic alcohol 
• 100-01-6 4-nitro-aniline 
• 788-25-0 2-((4-nitrophenylimino)methyl)phenol 
• 90-02-8 salicylaldehyde 
• 788-25-0 2-{[(E)-4-Nitro-phenylimino]-methyl}-phenol 
• 89-95-2 2-methyl-benzyl alcohol 

Downstream Products

• 70301-61-0 3-chloro-5-(4-nitro-phenyl)-5,6-dihydro-benzo[f]pyridazino[3,4-b][1,4]oxazepine 
• 139554-00-0 10-(4-Nitro-phenyl)-2-phenyl-9,10-dihydro-4-oxa-2,10-diaza-benzo[f]azulene-1,3-dione 
• 99779-31-4 2-chloro-N-(2-hydroxybenzyl)-N-(4-nitrophenyl)acetamide 
• 139554-05-5 4'-[(2-Hydroxy-benzyl)-(4-nitro-phenyl)-amino]-1'-phenyl-2,3,4,5-tetrahydro-[1,3']bipyrrolyl-2',5'-dione 

Relevant academic research and scientific papers

A simple method for the reduction of Schiff bases using biosynthesized nickel oxide nanoparticles

An innovative and simple approach for the reduction of aldimines to the corresponding secondary amines was described using biosynthesized nickel oxide nanoparticles as heterogeneous catalyst and ammonium formate as the hydrogen donor. This catalytic trans

Screening of simple carbohydrates as a renewable organocatalyst for the efficient construction of 1,3-benzoxazine scaffold

A convenient protocol for the two component preparation of 1,3-benzoxazines by using several protected and unprotected carbohydrate molecules as organocatalysts have been developed which is broadly applicable to condensation reaction between variety of Ma

Structure-activity relationship study of E6 as a novel necroptosis inducer

Necroptosis inducers represent a promising potential treatment for drug-resistant cancer. We herein describe the structure modification of E6, which was identified recently as a potent and selective necroptosis inducer. The studies described herein demonstrate for the first time that functionalized biphenyl derivatives possess necroptosis inducer activity. Furthermore, these studies have led to the identification of two promising compounds (5h and 5j) that can be used for further optimization studies as well as mechanism of action investigations.

Synthesis and structure-antibacterial activity relationship studies of 4-substituted phenyl-4,5-dihydrobenzo[f][1,4]oxazepin-3(2H)-thiones

The synthesis and characterization of a series of 4-substituted phenyl-4,5-dihydrobenzo[f][1,4]oxazepin- 3(2H)-thiones were presented. Preliminary in vitro antimicrobial activity of the compounds was assessed against a panel of microorganisms including S.

Sodium borohydride on wet clay: Solvent-free reductive amination of carbonyl compounds using microwaves

A solvent-flee reductive amination of carbonyl compounds by wet montmorillonite K 10 clay supported sodium borohydride is described; microwave irradiation facilitates the procedure.

Qualitative analysis of the stability of the oxazine ring of various benzoxazine and pyridooxazine derivatives with proton nuclear magnetic resonance spectroscopy

A series of 3,4-dihydro-1,3-benzoxazine and 3,4-dihydro-1,3-pyridooxazine derivatives was synthesized, and the hydrolysis of the derivatives was studied with proton nuclear magnetic resonance spectroscopy. The oxazine derivatives underwent various degrees of hydrolysis when H2O was added to dimethyl sulfoxide solutions of the compounds. The rates and extents of decomposition of the oxazine ring systems depended on the electronic effects of substituents within the molecules. Examination of the proton nuclear magnetic resonance spectra that were generated during decomposition of the oxazines and trends in stability of the oxazine derivatives suggest the formation of an intermediate in the hydrolysis mechanism.

THE SYNTHESIS AND REACTIONS OF 9,10-DIHYDROPYRROLOBENZOXAZEPINE DERIVATIVES WITH AMINES

In the reaction of the dichloromaleimides (3,4-dichloro-1H-pyrrole-2,5-dione) with N-substituted salicylamide and their analogs respective 9,10-dihydropyrrolo-benzoxazepine derivatives were obtained.These compounds reacting with amines form 2,

New Route for the Preparation of 2H-3-Aryl-3,4-dihydro-1,3-benzoxazines and 2H-3-Aryl-3,4-dihydro-4-methyl-1,3-benzoxazines

2-Hydroxybenzaldehyde (1) and 1-(2-hydroxyphenyl)ethanone (2) on reaction with different primary aromatic amines gave 2-(arylimino)methylphenols (3) and 2-phenols (4), respectively. 3 and 4 on reduction with sodium borohydride gave 2-(arylamino)methylphenols (5) and 2-phenols (6), which underwent cyclisation with formaldehyde to form 2H-3-aryl-3,4-dihydro-1,3-benzoxazines (7) and 2H-3-aryl-3,4-dihydro-4-methyl-1,3-benzoxazines (8), respectively.