13159-86-9Relevant academic research and scientific papers
Design, synthesis, evaluation and 3D-QSAR analysis of benzosulfonamide benzenesulfonates as potent and selective inhibitors of MMP-2
Qiu, Han-Yue,Wang, Zhong-Chang,Wang, Peng-Fei,Yan, Xiao-Qiang,Wang, Xiao-Ming,Yang, Yong-Hua,Zhu, Hai-Liang
, p. 39214 - 39225 (2014)
A novel series of MMPIs was designed, synthesized and purified using a scaffold modification strategy. The new compounds were also evaluated for biological activity against A549, MCF-7, HepG2 and Hela as potential inhibitors of MMP-2. The most potent inhi
Synthesis of 4-sulfamoylphenyl-benzylamine derivatives with inhibitory activity against human carbonic anhydrase isoforms I, II, IX and XII
Durgun, Mustafa,Turkmen, Hasan,Ceruso, Mariangela,Supuran, Claudiu T.
, p. 982 - 988 (2016/02/19)
Imine derivatives were obtained by condensation of sulfanilamide with substituted aromatic aldehydes. The Schiff bases were thereafter reduced with sodium borohydride, leading to the corresponding amines, derivatives of 4-sulfamoylphenyl-benzylamine. These sulfonamides were investigated as inhibitors of the human carbonic anhydrase (hCA, EC 4.2.1.1) isoforms hCA I and II (cytosolic isozymes), as well as hCA IX and XII (transmembrane, tumor-associated enzymes). We noted that the compounds incorporating secondary amine moieties showed a better inhibitory activity against all CA isozymes compared to the corresponding Schiff bases. Low nanomolar CA II, IX and XII inhibitors were detected, whereas the activity against hCA I was less potent. The secondary amines incorporating sulfonamide or similar zinc-binding groups, poorly investigated chemotypes for designing metalloenzyme inhibitors, may offer interesting opportunities in the field due to the facile preparation and possibility to explore a vast chemical space.
SODIUM BOROHYDRIDE REDUCTION OF AROMATIC SULFONYL AZIDES IN THE PRESENCE OR ABSENCE OF TELLURIUM
Obafemi, Craig. A.,Onigbinde, Adebayo O.
, p. 75 - 81 (2007/10/02)
Some aromatic sulfonyl azides have been reduced, in various solvents, with sodium borohydride, in the presence or absence of Te element to the corresponding sulfonamides.Other functionals groups like the imino group may also be reduced.
