131602-95-4Relevant academic research and scientific papers
Regio-controlled synthesis of 1, 4-benzothiazinones
Ghailane, Touria,Saadouni, Mohammed,Boukhris, Said,Habbadi, Nouzha,Hassikou, Amina,Kerbal, Abdelali,Garrigues, Bernard,Souizi, Abdelaziz
, p. 357 - 363 (2011)
Regio-controlled cyclization of gem-dicyanoepoxides with 2-aminothiophenol and its hydrochloride to form 1,4-benzothiazine-2-one or 3-one is described. The cyclization is highly regioselective and the reaction of the epoxides with 2-aminothiophenol under neutral reaction condition gave 1,4-benzothiazine-2-one as a sole cyclized product, whereas that with hydrochloride of 2-aminothiophenol afforded 1,4-benzothiazine-3-one predominantly. The regioselectivity resulted from the reaction condition is discussed. The Japan Institute of Heterocyclic Chemistry.
